Living systems operate far from equilibrium, relying on a complex network of biochemical processes
fueled by energy from their environment. However, this energy is often limited, and biochemical
systems must use it efficiently to maintain robust functioning. Despite the critical role of chemical
and metabolic networks in evolution, growth, and signaling, how energy constraints shape their
behaviors or the full range of their emergent properties remain elusive. Addressing these open
questions is essential for uncovering the fundamental principles that drive the complexity of life,
and the link between energetic and cellular functions. By drawing on concepts from physics, we can
better understand how living organisms optimize their limited energy resources and potentially
apply these insights to the design of new materials with life-like properties.
The aim of this workshop is to propose a program that bridges different fields—stochastic
thermodynamics, metabolic networks, and synthetic life—creating a connection among theoretical,
computational, and experimental scientists to tackle these challenges. A 2-week program will be
essential to start building such a unique community and delineate the research line to pursue in
concerted efforts to investigate the fundamental design principles of living organisms. We believe
that theoretical questions should be inspired by experimental and computational challenges, and
in turn, inspire further promising explorations.